Serie A official line-ups: Roma vs. Fiorentina
Roma hope Donyell Malen and Matias Soulé can get them within a point of Juventus and fourth place, as Fiorentina rely on Manor Solomon.
It kicks off at the Stadio Olimpico in Rome at 19.45 UK time (20.45 CEST).
This could be a big crossroads in the campaign, because as Juventus and Como were both held to draws, it gives Roma the opportunity to close within a point of fourth place and Champions League qualification.
Neil El Aynaoui is suspended, with Lorenzo Pellegrini, Artem Dovbyk and Evan Ferguson injured, plus Manu Kone, Zeki Celik and Bryan Zaragoza not at 100 per cent.
Paulo Dybala had been tipped for a return to the starting XI for the first time since January 25, making his comeback as a substitute in the 2-0 win away to Bologna, but he is again on the bench.
It’s barely been possible to see the front three of Malen, Dybala and Soulé start together.
Fiorentina are practically safe, but want one more push to be absolutely sure of escaping the relegation zone after a seven-round unbeaten Serie A run.
Their last two were stalemates against Sassuolo and Lecce, but Moise Kean, Roberto Piccoli, Niccolò Fortini and Tariq Lamptey are all still injured.
Robin Gosens and Fabiano Parisi are back in the squad, but Albert Gudmundsson has to be a False 9 with Jack Harrison and Manor Solomon in support.
Roma vs. Fiorentina line-ups
Roma: Svilar; Mancini, Ndicka, Hermoso; Celik, Cristante, Koné, Wesley; Soulé, Pisilli; Malen
Fiorentina: De Gea; Dodo, Pongracic, Ranieri, Gosens; Ndour, Fagioli, Brescianini; Harrison, Gudmundsson, Solomon