Marriage status has surprising link to cancer risk, study suggests: 'Clear signal'

Adults who never married are significantly more likely to develop cancer, according to new research from the University of Miami.

A large study of more than four million Americans across 12 states found that this increased risk spans nearly every major cancer type. It is especially true for preventable cancers, such as types caused by smoking and infection.

Men who never married were found to have a 70% higher likelihood of cancer than their married counterparts. For women, that gap was even wider, with never-married individuals facing an 85% higher risk.

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Previous research has linked marriage to better survival rates after a diagnosis, but this is one of the first studies to show that marital status could be a major indicator of whether a person will develop cancer in the first place.

"These findings suggest that social factors such as marital status may serve as important markers of cancer risk at the population level," study co-author Paulo Pinheiro, a research professor of epidemiology at the University of Miami Miller School of Medicine, said in a press release.

Between 2015 and 2022, the team examined cancer cases diagnosed at age 30 or older and compared the rates of various cancers to marital status of participants. They then broke down the data by sex and race and adjusted for age.

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Adult men who were never married had approximately five times the rate of anal cancer compared to married men, the study found.

Adult women who were never married had nearly three times the rate of cervical cancer compared to women who were or had been married.

"It’s a clear and powerful signal that some individuals are at a greater risk," Frank Penedo, director of the Sylvester Survivorship and Supportive Care Institute at the University of Miami, said in the release.

For women, being married (and often, by extension, having children) was associated with lower risks of ovarian and endometrial cancers, likely due to hormonal and biological factors associated with pregnancy, according to the researchers.

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Experts stressed that these findings do not mean marriage alone can protect against cancer.

"It means that if you’re not married, you should be paying extra attention to cancer risk factors, getting any screenings you may need, and staying up to date on healthcare," Penedo said.

The researchers also hypothesized that people who smoke less, drink less and take better care of themselves may be more likely to get married, meaning other factors could influence the findings.

More research is needed to confirm the outcome, they noted.

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The study was published in the journal Cancer Research Communications.