Jamie-Lynn Sigler Talks Playing a Doctor with MS on 'Grey's Anatomy,' Reveals If She'll Ever Return Again

Jamie-Lynn Sigler just made her TV comeback with a guest spot on Grey’s Anatomy, playing a doctor with MS to mirror her real-life diagnosis.

While the 44-year-old actress was diagnosed with MS when she was just 20, she kept it a secret until 2016.

“I was approached by the Grey’s team almost a year ago about coming on the show and playing a role with MS, and my only input was that I wanted to show someone in their power. I didn’t want to show somebody that was needing help per se, or in any medical need,” Jamie-Lynn told Deadline.

She continued, “I wanted to show somebody that was living with this diagnosis for some time, accepting of their circumstances, acknowledging the hardships and the reality of what it is to live with a chronic illness but somebody that’s made the adjustments in their life to continue to pursue their dreams and what they love, and they delivered that above and beyond.”

This marked Jamie-Lynn‘s first TV appearance since her role on ABC’s Big Sky back in 2023.

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“I think this is the year that I’m stepping into my power a little bit more, my authenticity. I’ve felt it inform my work, I feel like I’m doing my best work. Yes, I’m fully putting myself back out there and looking forward to the things that are on the horizon,” she said.

Jamie-Lynn is open to reprising her role on Grey’s in future episodes!

She said, “The last line is, literally, ‘you have my number.’ The people at Grey’s have my number. I think they know how much I enjoyed my time there, and it would, of course, be my honor to come back and play with them anytime.”

A beloved Grey’s actress is returning for an episode later this month!