Here's what the star-studded voice cast of Netflix's 'Big Mouth' looks like in real life

Kroll played several human characters, including Nick Birch, the series' lead character, who was inspired by Kroll's childhood.

Kroll also played Lola Skumpy and Coach Steve, Andrew's hormone monster, Maury, and Nick's hormone monster, Rick.

Kroll is known for starring in the FX comedy "The League," creating and starring in his own sketch series "Kroll Show," and creating the "Big Mouth" spinoff series "Human Resources."

Andrew Glouberman, a boy obsessed with masturbation, is Nick Birch's best friend who joins him on his adventure through puberty.

John Mulaney, a comedian and former "Saturday Night Live" writer, plays the character. Mulaney has starred in other animated movies, including "Puss in Boots: The Last Wish" and "Spider-Man: Into the Spider-Verse."

Jessi Klein plays Jessi Glaser, a close friend of Nick and Andrew's who explores her sexuality and struggles with depression and her parents' divorce.

Klein is best known for her writing and producing work, having previously produced "Inside Amy Schumer," "Transparent," and "Dead to Me."

Maya Rudolph plays two characters in the series — Connie LaCienega, the hormone monster for Jessi, and Diane Birch, Nick's mother.

Rudolph, who rose to fame as a cast member on "Saturday Night Live," has won four primetime Emmy Awards for her performance in "Big Mouth" and has starred in numerous movies and TV shows, including "Bridesmaids," "The Good Place," and "The Lego Movie 2."

Missy is a nerdy biracial classmate of Andrew, Jessi, and Nick's.

In the first four seasons, Jenny Slate voiced the character, but she stepped down from the role in 2020, announcing on Instagram that black people should play black characters.

Slate was replaced with Ayo Edebiri as Missy began to explore her Black identity in the show.

Edebiri is best known for her breakout roles in the 2020s in "Bottoms" and "The Bear."

Thandiwe Newton played Missy's British hormone monster, Mona.

Newton is known for starring in "Westworld," "Mission: Impossible II," and "Solo: A Star Wars Story."

Jay Bilzerian, a sex-obsessed bisexual boy, is another friend of Andrew, Nick, and Jessi's.

Mantzoukas is a comedian who has previously played equally wacky characters in "Brooklyn Nine-Nine," "The Good Place," and "The League."

Matthew MacDell, a gossipy gay student, was initially a secondary character in the first few seasons but became one of the main characters after season 3, developing relationships with Jay and Jessi.

Broadway and screen actor Andrew Rannells has starred in "The Prom" and "Girls" and has a vibrant voice-acting career, appearing on shows like "Sonic X," "Pokémon," and "Invincible."

David Thewlis joined the cast in season two as the Shame Wizard, who will mock and bully the children to amplify their shame around their mistakes.

Thewlis previously starred in multiple "Harry Potter" movies, "Wonder Woman," and "The Theory of Everything."

Depression Kitty first shows up in season two after Jessi starts to develop strong negative emotions amid her parents' divorce. Since then, Depression Kitty has made a few appearances across the show.

Jean Smart, an Emmy-winning actor who stars in "Hacks," played Depression Kitty.

Tito the Anxiety Mosquito embodies the children's anxiety, first appearing in season four.

Comedian Maria Bamford is known for her comedy specials as well as her Netflix show "Lady Dynamite."

Danni is a student Nick meets in season seven when considering attending a private school.

Zazie Beetz is known for her roles in "Atlanta," "Deadpool 2," "Joker," and "Bullet Train."

In season seven, Megan Thee Stallion guest stars as Megan, a hormone monster for Danni.

Megan Thee Stallion is better known for her rapping career, though she has also starred in Disney+'s "She-Hulk: Attorney At Law" and the 2023 movie "Dicks: The Musical."

One of Nick's friends is the ghost of jazz pianist Duke Ellington, who lives in the teen's attic.

Jordan Peele is the voice behind the ghost. He also played Missy's father, Cyrus Foreman-Greenwald.

Peele is an Oscar-winning horror director and comedy actor best known for directing "Get Out," "Nope," and "Us" and starring in "Key and Peele."

Elijah, an asexual Christian student, appears in seasons six and seven, building a relationship with Missy. They broke up after graduating from middle school.

Brian Tyree Henry, known for his roles in "Atlanta," "Bullet Train," and Marvel's "Eternals," plays Elijah. Henry has voice acting experience from starring in the "Spider-Verse" movies as Miles Morales' father, Jefferson.

Natasha Lyonne guest stars in the final season as sex-ed teacher Ms. Dunn. Lyonne has also made cameos in previous seasons playing Suzette Saint James, Jay's pillow girlfriend, and Nadia Vulvokov, the character Lyonne plays in Netflix's "Russian Doll."

Lyonne is best known for starring in "American Pie," "Orange is the New Black," and "Poker Face."

Ali Wong joined "Big Mouth" in season three, playing the pansexual transfer student Ali.

Wong is a comedian who has previously starred in other Netflix originals like "Beef" and "Always Be My Maybe."

"Big Mouth" season five introduced the concept of Hateworms and Lovebugs, who strengthen the children's emotions. Rochelle, played by Keke Palmer, was Missy's Hateworm but later transformed into her Lovebug.

Palmer is best known for starring in "True Jackson, VP," "One of Them Days," and "Nope."