Dr. McCullough Weighs In: The History & Future of GLP-1s
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In a recent article by Dr. Peter McCullough, he explores the evolution of GLP-1 receptor agonists and their expanding role beyond diabetes treatment.
The journey began in 2005 with the FDA approval of exenatide (Byetta), setting the stage for a new class of medications that regulate blood sugar and appetite.
A Timeline of GLP-1 Advancements:
2005 – Exenatide (Byetta) approved for type 2 diabetes
2010 – Liraglutide (Victoza) enters the market
2017 – Semaglutide (Ozempic & oral Rybelsus) gains approval
2022 – Tirzepatide (Mounjaro) emerges as a dual-receptor agonist
These drugs influence key metabolic pathways, offering benefits for both diabetes and weight loss. However, they come with limitations—most require injections, clinical oversight, and ongoing prescriptions.
The Next Step: Retatrutide & The Power of Triple-Receptor Agonism
As Dr. McCullough discusses, retatrutide (LY3437943) represents the next evolution in GLP-1 therapies, targeting three key receptors:
– GLP-1 for appetite control & glucose regulation
– GIP to enhance insulin sensitivity
– Glucagon to promote fat metabolism
While injectable retatrutide is still under clinical investigation, early data suggests it is more effective than its predecessors. However, many individuals want a more flexible, private, and patient-controlled solution for weight loss.
Introducing DROP: A Revolutionary Approach to Weight Management
The Wellness Company developed DROP — an oral retatrutide formula — designed to support metabolic health without the barriers of traditional GLP-1 therapies.
Encapsulated in liposomes for enhanced absorption, DROP provides an alternative solution for those seeking appetite control and weight management in a non-injectable form.
If you’ve considered GLP-1 treatments but want a more discreet, adaptable option, click here to see if DROP may be the solution you’ve been looking for.
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Note: The information provided on this website is intended for informational purposes only and should not be considered medical advice or used as a substitute for professional healthcare guidance. It is your responsibility to comply with all applicable laws, regulations, and guidelines regarding the purchase, possession, and use of prescription medications.
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