49ers injury report vs. Buffalo: Purdy will play, other key players will not

SANTA CLARA — Brock Purdy will be back, but he’ll be missing key parts of his supporting cast.

A look at who is out and who is questionable Sunday for the 49ers’ road game against the Buffalo Bills:

OUT

Defensive end Nick Bosa, hip, oblique

Bosa last played in a 20-17 loss to Seattle. He went into the game with an oblique/hip injury, then strained the other side while recording his second sack and departing after 32 snaps. Stayed behind and rehabbed for last week’s loss to Green Bay — his first missed game since Oct. 16, 2022, a 28-14 road loss to Atlanta. Bosa was not on the field during the media window Friday.

Left tackle Trent Williams, ankle

Williams made it through the Seattle loss at what he estimated at 65 percent. The toll it took, however, was enough to keep him out against the Green Bay loss. A Pro Bowl player all four seasons with the 49ers and a first-team All-Pro for the last three, Williams has missed 11 games due to injury since joining the 49ers. Williams was not on the field during the media window Friday.

CB Deommodore Lenoir, knee

One of the 49ers’ top performers in 2024, Lenoir banged knees with an opponent against Green Bay and missed five snaps. He was held out of practice through Thursday. Lenoir was not on the field during the media window Friday.

Left guard Aaron Banks, concussion

Missed the last seven snaps of the loss to Packers and was placed on concussion protocol upon the 49ers’ return home, Banks missed two games in 2022-23 because of injury after assuming the starting job. Banks was not on the field during the media window Friday.

Defensive tackle Jordan Elliott, concussion

Considered one of the 49ers’ better interior run defenders, Elliott departed after 26 snaps against the Packers and hadn’t practiced through Thursday. Elliott was not on the field during the media window Friday.

Linebacker Dre Greenlaw, Achilles

Greenlaw just started practicing this week and wasn’t expected to be activated. The 49ers will want to see another week from him to determine if he can go from I.R. to the 53-man roster next week against Chicago.

QUESTIONABLE

Quarterback Brock Purdy, shoulder

Played in 48 games in four seasons at Iowa State, never missing one due to injury. Made 37 starts for the 49ers (31 in the regular season, six in the postseason) before emerging from the Seattle game on Nov. 17 with a shoulder injury. Purdy was throwing during warmups and drills during the media window Friday.

Linebacker Demetrius Flannigan-Fowles, knee

One of the 49ers’ better players on their much-maligned special teams as well as a spot linebacker, Flannigan Fowles departed after nine special teams snaps against Green Bay. Missed Weeks 5 and 6 with a calf injury. Flannigan-Fowles was not on the field during the media window Friday.

Wide receiver Chris Conley, knee

Reserve wide receiver and special teams player was apparently injured during Wednesday’s practice. He participated fully, but on Thursday was on the report for limited participation.

NOTABLE

— Sebastian Gutierrez was signed to his second practice squad stint this season. Gutierrez was also in the practice squads of Cleveland and Indianapolis this season and in previous years has been on the practice squads of New England, the Raiders and Kansas City. Cameron Erving, who was signed to the practice squad two days ago, was released.