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Mental Health Survival Kit, Chapter 2: Is Psychiatry Evidence Based? (Part 7)

Editor’s Note: Over the next several months, Mad in America will publish a serialized version of Peter Gøtzsche’s book, Mental Health Survival Kit and Withdrawal from Psychiatric Drugs. In this blog, he discusses the colossal overprescribing of prescription pills. Each Monday, a new section of the book will be published, and all chapters will be archived here.

The final nails in the coffin of biological psychiatry

When I discuss the state of psychiatry with critical psychiatrists, psychologists and pharmacists I collaborate with, we sometimes ask each other: “Who are most mad, on average, the psychiatrists or their patients?”

This is not as far-fetched or rhetorical a question as it may seem. When I Googled delusion, the first entry was from an Oxford dictionary: “An idiosyncratic belief or impression maintained despite being contradicted by reality or rational argument, typically as a symptom of mental disorder.”

As you have already seen, right from the start of Chapter 1, and will see more of in the following, the whole of psychiatry is characterised by exactly this. The psychiatrists’ predominant idiosyncratic beliefs are not shared by people considered sane, i.e. the general public, but the psychiatrists forcefully maintain them, even when reality, including the most reliable science we have, and rational argument clearly show that their basic beliefs are wrong.

If psychiatry had been a business, it would have gone bankrupt, so let’s conclude instead that it is morally and scientifically bankrupt.

One definition of madness is doing the same thing again and again expecting a different result. When a drug doesn’t seem to work so well, which is most of the time, psychiatrists increase the dose, change to another drug from the same class, add another drug from the same class, or add a drug from another class.

The science tells us very clearly that these maneouvres will not benefit the patients. Switching drugs, adding drugs or increasing the dose do not result in better outcomes.156-158 What is certain is that increasing the total dose or number of drugs will increase the occurrence of serious harms, including irreversible brain damage, suicides and other deaths.4,159,160 Neuroleptics shrink the brain in a dose-dependent manner; in contrast, the severity of illness has minimal or no effect.160

There is no reliable evidence that the psychosis per se can damage the brain.161 The same applies to other psychiatric disorders, but psychiatrists often lie to their patients, telling them that their disease might harm their brains if they do not take psychiatric drugs. Psychiatry professor Poul Videbech wrote in 2014 that depression doubles the risk of dementia,162 but the meta-analysis he cited did not mention with one word which treatments the patients had received.163 Other studies indicate that it is the drugs that make people demented.164,165

It is routine everywhere to increase the dose, even when the patient has become better. An often-heard comment at conferences at psychiatric wards is: “The patient is doing well after two weeks on Zyprexa, so I will double the dose.” This routine is both insane and harmful. The psychiatrist cannot know if the patient might have improved more without Zyprexa. The doctors mislead themselves and their patients all the time based on their misleading “clinical experience” and their treatment rituals go directly against the science.

In this way, many patients end up on terribly harmful drug cocktails they might never escape from. Although it’s hard to believe, it’s getting worse. A US study of office-based psychiatry found that the number of psychotropic medications prescribed increased markedly in just nine years up to 2006: visits with three or more medications doubled, from 17% to 33%.166 Prescriptions for two or more drugs from the same class also increased, although this shouldn’t happen at all.

I was once invited to follow the chief psychiatrist during one day at a closed ward. We talked with several patients. One of them appeared totally normal and reasonable to me, but to my big surprise, the psychiatrist asked me afterwards if I could see that he was delusional. As I couldn’t, he explained the patient was delusional because he had been on the Internet and had found out that neuroleptics are dangerous. I replied that they are indeed dangerous and that there is nothing delusional in believing this. I was so stunned that I said no more.

On another occasion, I phoned a psychiatric department in Copenhagen that has a very bad reputation because of the patients the psychiatrists have killed there with their drugs.45 A desperate patient in great distress had rung me, but it wasn’t possible for me to get through to a psychiatrist, although I am a colleague and it was within normal working hours.

I insisted that I needed to talk to someone and was transferred to a head nurse. She told me not to become involved because the patient was delusional. When I asked in what way, she said he had found out that neuroleptics were dangerous. I asked her if she knew whom she was talking to. Oh yes, she knew about me.

I shall now illustrate more of the absurd, delusional world of psychiatry with some examples.

One of my psychiatrist friends sent a letter to a family doctor about a 21-year-old student, recently discharged from a private hospital after she had been given TMS 21 times. When I asked what this is, my friend replied: “Transcranial Magnetic Stimulation, the latest in a long line of crackpot fads to hit psychiatry, designed to separate the worried well from their money.”

When she became increasingly anxious, she was given 12 electroshocks. She had two diagnoses, borderline personality disorder and bipolar affective disorder, and was discharged on these drugs (prn: as needed; bd: twice daily):

Chart of medications

This is insane and constitutes gross medical malpractice. No one in the whole world knows what will happen when all these drugs are given together, only that it is far more dangerous than if fewer drugs are used.

The referral letter notes that the patient sleeps heavily and her appetite is excessive. She is trying to diet, as she has gained about 50 kg with the drugs. She has little energy, interest, or motivation, doesn’t exercise or mix socially, and has no sexual interest. She has bouts of feeling low and miserable with occasional suicidal ideas due to not liking herself, and also has bouts of feeling “manic,” during which she is unpleasantly agitated and tends to overspend in the hope of feeling better.

She also has frequent bouts of agitation and irritability and has described classic akathisia. She has no paranoid ideas and she is ritualistic about security and order but there are no true obsessive-compulsive features. She has been anxious since primary school.

My colleague ended his letter by telling the family doctor that this case was a perfect demonstration of why he had published major objections to mainstream psychiatry. The patient had an anxious personality with secondary depression and did not have borderline personality disorder; apart from this, none of the people using this diagnosis could say what it borders on.

“If she stays on this level of drugs, she will be dead by forty. She is aware of this and wants them reduced but they are all highly addictive and can produce severe withdrawal states, which mimic major mental disorder.”

A court case I have been involved with is no different. It is a typical story that illustrates the role of a depression pill as “Psychiatry’s Starter Kit.”

As far as I can see, this young man should never have been offered a psychiatric drug. He should have been offered psychotherapy for his problems that seemed to be transient. On top of this, he was functioning well when his psychiatrist decided to put him on a depression pill for “depression.”

His psychiatric “career” lasted 33 years before he finally succeeded to come off the last drug, but he still suffers from long-lasting withdrawal effects. His drug list during all these years is mind-blowing. He was prescribed the three main types of psychiatric drugs, sedatives/ hypnotics, depression pills and neuroleptics, on and off in various combinations, amounting to a total of three different sedatives/ hypnotics, five depression pills and six neuroleptics.

He also developed Parkinsonism, very likely drug induced, and was treated also for that. Sedatives/hypnotics were prescribed for about 10 years, depression pills for about 25 years, and neuroleptics for about 30 years, and there was a considerable degree of polypharmacy.

It is remarkable that anyone can survive all this and continue being employed.

The psychiatrist stopped the drugs abruptly many times. Not tapering off slowly these drugs after having put a patient on them for long periods of time constitutes highly dangerous malpractice.

I hope he will win the case, but unfortunately, judges are very authoritarian and always emphasize what other psychiatrists do in similar situations. This is wise, as a general precaution, but not when virtually everyone is at fault. If a bank defrauds its customers, it doesn’t help in court that other banks do the same. Then why is everyone excused in psychiatry? How will it ever be possible to win cases, given this injustice?

Occasionally, a case is won.4 Wendy Dolin in Chicago sued GlaxoSmithKline after her husband, a highly successful lawyer who loved life and had no psychiatric issues, was put on paroxetine because he developed some anxiety regarding work. He got akathisia and threw himself in front of a train six days after starting paroxetine, not realising it wasn’t him that had gone mad; it was the pill that made him mad. Baum & Hedlund in Los Angeles won the case, but then? GlaxoSmithKline appealed the verdict.

When Wendy heard I had arranged a meeting about psychiatry in relation to my book launch in 2015,4 she decided to go to Copenhagen and tell her story. Four other women who had lost a husband, a son, or a daughter to drug-induced suicide when there was absolutely no good reason to prescribe a depression pill also came, on their own account. My programme was already full, but I made room for them. This was the most moving part of the whole day. There was stunning silence while they recounted their stories, which can be seen on YouTube.167

The colossal use of psychiatric drugs is not evidence-based but is driven by commercial pressures. I studied whether two widely differing drug classes, neuroleptics and depression pills, showed similar patterns in long-term usage. The usage patterns ought to be very different because the main indication for neuroleptics, schizophrenia, has traditionally been perceived as a chronic condition whereas the main indication for depressions pills, depression, has been perceived as episodic.

However, they were not different. They were the same:169

Percentage of current users in Denmark who redeemed a prescription for the same or a similar drug in each of the following years after 2006.

Graph of depression pill and neuroleptic prescriptions

I started the clock in 2006, following patients onwards in time. That year, 2.0% of the Danish population deemed a prescription for a neuroleptic and 7.3% for a depression pill. Many of the patients had already taken their drug for years, but this group of people also included some who were first-time users in 2006, namely 19.8% vs. 20.0%. This was a remarkably similar percentage for two groups of widely different drugs used for widely different disorders.

The patients got a new prescription every single year till they stopped or came to 2016, my last observation year, when 35% vs. 33% of the patients were still on treatment.

These results are shocking. Whatever the flawed guidelines might have tried to tell doctors, they didn’t work as expected, and drug usage was clearly not evidence based. I almost felt I had discovered a new law in nature. Contrary to our hunches, 1 kg of feathers fall with the same speed as 1 kg of lead, provided they fall in a vacuum, according to the law of gravity. Similarly, the usage of these two widely different classes of drugs fell with the same speed. A huge proportion of patients continue taking their drug, year in and year out, for more than a decade.

This is iatrogenic harm of epic proportions. The patients dislike the drugs so much that their doctors need to persuade them to take them. Such persuasion is not needed to motivate people to take baby aspirin after a heart attack to reduce the risk of a new attack. Neuroleptics are even forced upon patients against their will “for their own sake.” If not forced, few would take them.

When healthy people have taken a neuroleptic just to experience what it is like, they have told me, or have published, that they were incapacitated for several days!170 Difficulty reading or concentrating and an inability to work are common harms—but the whole body is affected. We cannot doubt the power of these toxins.

What we are seeing is the result of systematic deception of doctors and patients. The patients are routinely being asked to endure the harms because it may take some time before the drug effect sets in. They are not told that what they perceive as a drug effect is the spontaneous improvement that would have occurred without the drug, or that it can be difficult to come off the drug again. The lie about the chemical imbalance has also contributed. The patients often say that they are afraid of falling ill again if they stop taking their drug because they believe there is something chemically wrong with them.

Mainstream psychiatry doesn’t bother about evidence but will continue business as usual pretending my results don’t exist, and they will say that, “we all know that long-term treatment is good for people; if they don’t get their drugs, they will relapse.”

In 2014, Norwegian psychiatrists wrote about what they called an “alarmingly high discontinuation” rate of neuroleptics in patients with schizophrenia, 74% in 18 months. I would call this a healthy sign, but the psychiatrists argued it highlighted “the clinicians’ need to be equipped with treatment strategies that optimize continuous antipsychotic drug treatment.”171 Really? What about forced feeding with pills, like the Strasbourg geese are fed to produce foie gras? Neuroleptics make people fat. But psychiatrists don’t need to do this. When they don’t get their will, or the patients spit out the tablets, they can use depot injections.

Next, I decided to find out if there was a similar pattern of usage of benzodiazepines and similar agents (hypnotics/sedatives), lithium and stimulants (ADHD drugs).

Since we have known for decades that benzodiazepines and similar drugs are highly addictive and should only be used for up to four weeks (restricted use was recommended already in 1980 in the UK),172,173 and because the therapeutic effect disappears quickly, usage of such drugs ought to be very low, and by far most users in a given year should therefore be first-time users. This was not at all the case:174

Percentage of current users in Denmark who redeemed a prescription for the same or a similar drug in each of the following years after 2007.

Graph of benzodiazepine, stimulant, and lithium prescriptions

In 2007, 8.8% of the Danish population deemed a prescription for a benzodiazepine or similar agent, 0.24% for lithium and 0.16% for a stimulant. For benzodiazepines, only 13.0% were first-time users. For the two other drugs, the numbers were 40.4% and 11.2%, respectively.

The patients got a new prescription every single year till they stopped or came to 2017, my last observation year, when 18%, 29% and 40%, respectively, were still in treatment.

These findings are also disturbing. No matter which psychiatric drug people take or what their problem is, roughly one-third of the patients are still in treatment with the same drug or a similar one ten years later. For benzodiazepines and similar agents, continued use after ten years was “only” 18%, but given what we know about these drugs, it can be argued it should have been zero many years before 2017. This is a disaster.

The same can be said about the usage for the other four types of drugs, which was very similar as the span only went from 29% to 40% (see the figures).

If we accept the evidence-based premises that these drugs do not have worthwhile effects, particularly when considering their substantial harms, and that the patients generally dislike them, the data show colossal overuse of the drugs to a similar degree.

Psychiatry’s main focus for the next decades should be on helping patients withdraw slowly and safely from the drugs they are on, instead of telling them that they need to stay on them. But it won’t happen. Psychiatry’s focus is on itself—a kind of eternal selfie it sends to the world all the time.

Usage of psychiatric drugs continues to increase markedly in virtually all countries. In the UK, neuroleptic prescriptions increased by 5% per year on average and depression pills increased by 10%, from 1998 to 2010.175

In Denmark, the sales of SSRIs increased from a low level in 1992 almost linearly by a factor of 18, closely related to the number of products on the market that increased by a factor of 16 (r = 0.97, which is an almost perfect correlation).176 This confirms that usage is determined by marketing.

It took almost 30 years after we had the evidence before it became generally accepted that benzodiazepines are addictive.172 This was expected and should have been investigated from the beginning because their forerunners, the barbiturates, are highly addictive. The first barbiturate, barbital, was introduced in 1903, but it took 50 years before it was accepted that barbiturates are addictive.

Benzodiazepine dependence was documented in 1961 and described in the BMJ in 1964. Sixteen years later, the UK Committee on the Review of Medicines published a systematic review of benzodiazepines,173 concluding that the addiction potential was low, estimating that only 28 persons had become dependent from 1960 to 1977. The fact was that millions had become dependent. In 1988, the Medicines Control Agency finally woke up and wrote to doctors about their concerns.172

But the party went on, and history repeated itself. The declining use of benzodiazepines was replaced by a similar increase in the use of depression pills,176 and a lot of what was previously called anxiety and treated with benzodiazepines was now conveniently called depression.5 Drug companies, clinicians and authorities denied for decades that depression pills also make people dependent.172

We did a systematic review of the withdrawal symptoms and found that they were described with similar terms for both benzodiazepines and SSRIs, and were very similar for 37 of 42 identified symptoms.177

Our 2018 study of 39 popular websites from 10 countries was also revealing:32 28 websites warned patients about withdrawal effects, but 22 stated that SSRIs are not addictive; only one stated that the pills can be addictive and warned that people “may get abstinence symptoms.”

Imipramine came on the market in 1957, and a paper from 1971 describes dependence with this drug when it was tested in six healthy volunteers.178 As I wrote on the first page in this book, 78% of 2,003 lay people regarded depression pills as addictive in 1991.179

Thus, we have known for 50 years or more that depression pills are addictive, and the patients have known it for at least 30 years, but 50 years after we knew it, the dependence problem was still being trivialised by the UK Royal College of Psychiatrists and the National Institute for Health and Care Excellence (NICE),180 and in the rest of the world, too.

 

To read the footnotes for this chapter and others, click here.





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